Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


 1.00 91
Y-27632   C14H21N3O • 2HCl • H2O 338.30 ROCK Watanabe K. (2007) Nature Biotech. 25 681
Chitaley K. (2001) Nat. Med. 7 119

10.00 83
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


 10.00 85
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


 1.00 85
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


 10.00 9
Chelerythrine Chloride   C21H18NO4Cl 383.80 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209
Jarvis W.D. (1994) Cancer Res. 54 1707
WO2003077917
 1.00 57
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869
Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

10.00 26
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 87
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 90
2-Aminopurine   C5H5N5 135.13 PKR

100.00 90