Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


10.00 10
Piceatannol   C14H12O4 244.20 PKA, SYK Wang B.H. (1998) Planta Med. 64 195
Keely P.J. and Parise L.V. (1996) J. Biol. Chem. 271 26668
WO2012021964
1.00 101
Piceatannol   C14H12O4 244.20 PKA, SYK Wang B.H. (1998) Planta Med. 64 195
Keely P.J. and Parise L.V. (1996) J. Biol. Chem. 271 26668
WO2012021964
10.00 114
Pirfenidone   C12H11NO 185.23 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125
Iyer (1999) J.Pharmacol.Exp.Ther. 289 211
WO2005040758
10.00 99
Pirfenidone   C12H11NO 185.23 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125
Iyer (1999) J.Pharmacol.Exp.Ther. 289 211
WO2005040758
1.00 114
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


1.00 15
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


10.00 3
Vemurafenib   C23H18ClF2N3O3S 489.92 B-RAF Bollag G. (2010) Nature 467 596-9


1.00 101
Vemurafenib   C23H18ClF2N3O3S 489.92 B-RAF Bollag G. (2010) Nature 467 596-9


10.00 105
PLX 4720 (Raf Kinase Inhibitor V)   C17H14ClF2N3O3S 413.83 B-Raf Tsai J. (2008) Proc Natl Acad Sci USA. 3041-6

WO2011028540
10.00 95