This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.
We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.
If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.
If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.
| Inhibitor | Brutto | MW | Action | Reference | Screen Conc | % Activity Remaining |
|---|---|---|---|---|---|---|
| Novartis 12a (PKD1) | C23H29F3N6O3 | 494.51 | PKD1 |
Meredith E.L. (2010) J.Med.Chem. 53 5422-5438 |
10.00 | 21 |
| Novartis 12a (PKD1) | C23H29F3N6O3 | 494.51 | PKD1 |
Meredith E.L. (2010) J.Med.Chem. 53 5422-5438 |
1.00 | 84 |
| OSU-03012 | C26H19F3N4O | 460.45 | PDK1 |
Zhu J. (2004) Cancer Res. 64(12) 4309-18 |
10.00 | 83 |
| OSU-03012 | C26H19F3N4O | 460.45 | PDK1 |
Zhu J. (2004) Cancer Res. 64(12) 4309-18 |
1.00 | 86 |
| OTSSP167 | C25H28Cl2N4O2 | 487.42 | MELK |
|
0.10 | 61 |
| OTSSP167 | C25H28Cl2N4O2 | 487.42 | MELK |
|
1.00 | 7 |
| Parthenolide | C15H20O3 | 248.32 | IKKβ |
Kwok B.H. (2001) Chem. Biol. 8 759-766 |
1.00 | 98 |
| Parthenolide | C15H20O3 | 248.32 | IKKβ |
Kwok B.H. (2001) Chem. Biol. 8 759-766 |
5.00 | 125 |
| PCI-32765 (Ibrutinib) | C25H24N6O2 | 440.50 | Btk |
Honigberg L.A. (2010) Proc Natl Acad Sci 107 13075-13080 |
0.10 | 103 |
| PCI-32765 (Ibrutinib) | C25H24N6O2 | 440.50 | Btk |
Honigberg L.A. (2010) Proc Natl Acad Sci 107 13075-13080 |
10.00 | 111 |