Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
PLX 4720 (Raf Kinase Inhibitor V)   C17H14ClF2N3O3S 413.83 B-Raf Tsai J. (2008) Proc Natl Acad Sci USA. 3041-6

WO2011028540
 1.00 100
PP2   C15H16ClN5 301.77 Src Kirihara T. (2013) Exp Eye Res. S0014

WO2006068760
 10.00 91
PP2   C15H16ClN5 301.77 Src Kirihara T. (2013) Exp Eye Res. S0014

WO2006068760
 1.00 101
PP242   C16H16N6O 308.30 mTOR Feldman ME (2009) PLoS Biol 7(2)


 1.00 82
PP242   C16H16N6O 308.30 mTOR Feldman ME (2009) PLoS Biol 7(2)


 0.10 106
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639


 1.00 101
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639


 0.10 106
PRT062607   C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387


 10.00 80
PRT062607   C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387


 1.00 95
Purvalanol A   C19H25ClN6O 388.90 cyclin-dependent kinases Gray N.S. (1998) Science 281 533


0.10 112