Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
BI 2536   C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322


 1.00 120
BI-78D3   C13H9N5O5S2 379.37 JNK Stebbins J.L. (2008) PNAS 105 16809-16813


 0.10 100
BI-78D3   C13H9N5O5S2 379.37 JNK Stebbins J.L. (2008) PNAS 105 16809-16813


 1.00 95
BI-D-1870   C19H23N5O2F2 391.42 RSK Sapkota G.P. (2007) Biochem. J. 401 29–38

WO2003020722
 10.00 93
BI-D-1870   C19H23N5O2F2 391.42 RSK Sapkota G.P. (2007) Biochem. J. 401 29–38

WO2003020722
 1.00 102
BI605906 (BIX02514)   C17H22F2N4O3S2 432.51 IKKβ Clark K. (2011) Biochem. J. 434 93-104


 0.10 94
BI605906 (BIX02514)   C17H22F2N4O3S2 432.51 IKKβ Clark K. (2011) Biochem. J. 434 93-104


 1.00 92
BIO (6-Bromoindirubin-3'-oxime)   C16H10BrN3O2 356.20 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957
Polychronopoulos P. (2004) J. Med. Chem. 47 935
WO2007016485
 0.10 94
Blebbistatin   C18H16N2O2 292.30 myosin II Shu S. (2005) Proc. Natl. Acad. Sci. USA 102 1472
Kovacs M. (2004) J. Biol. Chem. 279 35557
WO2012062819
 10.00 91
BML-258 (SK1-I)   C17H28ClNO2 313.86 SphK1 Paugh S.W. (2008) Blood 112 1382-1391


 1.00 99