Inhibitor | IRAK 1-4 Inhibitor 1  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
IRAK 1-4 Inhibitor 1   C20H21N5O4 395.41 509093-47-4 11983295 IRAK1, IRAK4 Powers J. P. (2006) Bioorg. Med. Chem. Lett. 16 2842-2845

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 89 15
AMPK (hum) 115 1
ASK1 82 18
Aurora A 110 3
Aurora B 112 3
BRK 89 1
BRSK1 107 7
BRSK2 86 29
BTK 74 27
CAMK1 98 12
CAMKK beta 55 3
CDK2-Cyclin A 84 4
CDK9-Cyclin T1 42 1
CHK1 81 29
CHK2 97 11
CK1 delta 48 1
CK1 gamma 2 48 5
CK2 112 9
CLK2
6
 2
CSK 89 4
DAPK1 127 2
DDR2 107 18
DYRK1A 48 12
DYRK2 93 6
DYRK3 89 4
EF2K 114 1
EIF2AK3 98 3
EPH-A2 100 12
EPH-A4 90 2
EPH-B1 99 10
EPH-B2 69 1
EPH-B3 133 25
EPH-B4 100 6
ERK1 130 1
ERK2 101 13
ERK5 81 2
ERK8 105 9
FGF-R1 120 12
GCK 82 1
GSK3 beta 71 1
HER4 103 10
HIPK1 87 2
HIPK2 78 3
HIPK3 87 11
IGF-1R 82 10
IKK beta 82 5
IKK epsilon 90 3
IR 81 9
IRAK1
6
 2
IRAK4
9
 3
IRR 71 1
JAK2 70 7
JNK1 103 8
JNK2 96 1
JNK3 87 5
Lck 94 8
LKB1 74 4
MAP4K3 69 5
MAP4K5 75 0
MAPKAP-K2 91 0
MAPKAP-K3 99 5
MARK1 91 5
MARK2 93 4
MARK3 92 1
MARK4 95 6
MEKK1 92 4
MELK 86 0
MINK1 51 2
MKK1 71 7
MKK2 92 16
MKK6 104 13
MLK1 65 1
MLK3 54 4
MNK1 88 1
MNK2 64 15
MPSK1 82 4
MSK1 96 4
MST2 99 5
MST3 99 11
MST4 96 8
NEK2a 80 31
NEK6 117 2
NUAK1 63 3
OSR1 106 4
p38 alpha MAPK 99 5
p38 beta MAPK 117 3
p38 delta MAPK 118 26
p38 gamma MAPK 83 18
PAK2 94 8
PAK4 61 2
PAK5 76 8
PAK6 87 4
PDGFRA 98 6
PDK1 97 14
PHK 71 8
PIM1 97 0
PIM2 100 13
PIM3 85 5
PINK 106 5
PKA 91 2
PKB alpha 104 1
PKB beta 86 2
PKC alpha 100 4
PKC gamma 88 1
PKC zeta 92 16
PKD1 82 5
PLK1 70 1
PRAK 96 1
PRK2 94 3
RIPK2 109 19
ROCK 2 82 6
RSK1 81 12
RSK2 74 3
S6K1 88 6
SGK1 73 11
SIK2 84 5
SIK3 99 25
SmMLCK 115 14
Src 109 9
SRPK1 91 7
STK33 94 1
SYK 100 10
TAK1 28 2
TAO1 88 3
TBK1 67 8
TESK1 99 2
TGFBR1 112 1
TIE2 80 16
TLK1 92 1
TrkA 20 3
TSSK1 97 15
TTBK1 95 1
TTBK2 118 7
TTK 73 2
ULK1 101 10
ULK2 96 4
VEGFR1 84 7
WNK1 94 5
YES1 102 5
ZAP70 117 5
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 90 5
AMPK (hum) 107 6
ASK1 84 24
Aurora A 98 3
Aurora B 102 4
BRK 82 4
BRSK1 104 17
BRSK2 107 38
BTK 52 3
CAMK1 93 14
CAMKK beta 68 8
CDK2-Cyclin A 62 11
CDK9-Cyclin T1 14 3
CHK1 102 8
CHK2 90 7
CK1 delta 47 3
CK1 gamma 2 17 9
CK2 104 4
CLK2
4
 1
CSK 76 2
DAPK1 116 13
DDR2 98 0
DYRK1A 51 14
DYRK2 84 4
DYRK3 79 6
EF2K 102 5
EIF2AK3 100 4
EPH-A2 107 4
EPH-A4 71 1
EPH-B1 93 4
EPH-B2 47 24
EPH-B3 80 12
EPH-B4 94 9
ERK1 125 8
ERK2 90 8
ERK5 66 3
ERK8 72 1
FGF-R1 117 16
GCK 29 2
GSK3 beta 67 2
HER4 97 6
HIPK1 77 14
HIPK2 72 6
HIPK3 67 12
IGF-1R 61 0
IKK beta 74 4
IKK epsilon 83 5
IR 60 8
IRAK1
6
 5
IRAK4 12 1
IRR 56 15
JAK2 63 10
JNK1 66 3
JNK2 81 6
JNK3 41 1
Lck 89 11
LKB1 75 1
MAP4K3 14 2
MAP4K5 31 1
MAPKAP-K2 76 14
MAPKAP-K3 87 7
MARK1 87 17
MARK2 82 15
MARK3 82 8
MARK4 70 1
MEKK1 88 9
MELK 45 6
MINK1
10
 1
MKK1 77 11
MKK2 73 4
MKK6 104 10
MLK1 20 3
MLK3 39 1
MNK1 98 7
MNK2 79 2
MPSK1 41 1
MSK1 92 7
MST2 100 17
MST3 83 3
MST4 105 16
NEK2a 89 22
NEK6 115 5
NUAK1 34 10
OSR1 97 5
p38 alpha MAPK 96 7
p38 beta MAPK 110 42
p38 delta MAPK 112 9
p38 gamma MAPK 73 5
PAK2 90 3
PAK4 50 10
PAK5 45 2
PAK6 63 13
PDGFRA 85 20
PDK1 104 9
PHK 60 15
PIM1 100 5
PIM2 102 19
PIM3 81 10
PINK 99 8
PKA 95 2
PKB alpha 97 7
PKB beta 85 3
PKC alpha 103 6
PKC gamma 86 1
PKC zeta 76 18
PKD1 84 13
PLK1 75 2
PRAK 94 7
PRK2 88 0
RIPK2 93 13
ROCK 2 82 8
RSK1 73 13
RSK2 69 4
S6K1 81 1
SGK1 79 6
SIK2 74 3
SIK3 72 3
SmMLCK 114 3
Src 116 1
SRPK1 91 5
STK33 48 1
SYK 97 2
TAK1 23 8
TAO1 90 8
TBK1 99 12
TESK1 95 1
TGFBR1 99 8
TIE2 83 13
TLK1 77 9
TrkA 22 0
TSSK1 90 3
TTBK1 91 4
TTBK2 117 5
TTK 72 2
ULK1 82 5
ULK2 90 3
VEGFR1 83 9
WNK1 98 4
YES1 59 1
ZAP70 106 1