Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Parthenolide C15H20O3 248.32 IKKβ Kwok B.H. (2001) Chem. Biol. 8 759-766


5.00 107
Parthenolide C15H20O3 248.32 IKKβ Kwok B.H. (2001) Chem. Biol. 8 759-766


1.00 111
PD 0325901   C16H14F3IN2O4 482.19 MEK1 Bain J. (2007) Biochem J. 408 297–315.
Barrett SD. (2008) Bioorg. Med. Chem. Lett. 18 6501-6504.
WO2002006213
1.00 104
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


1.00 21
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


0.10 68
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


10.00 6
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


1.00 3
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


10.00 1
PRT062607   C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387


0.10 92
PRT062607   C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387


10.00 22