Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
H-89, Dihydrochloride | C20H20BrN3O2S • 2HCl | 519.30 | 127243-85-0 | 5702541 | PKA | Leemhuis J. (2002) J. Pharmacol. Exp. Ther. 300 1000 | Davies S.P. (2000) Biochem. J. 351 95 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 94 | 4 |
AMPK | 24 | 0 |
AMPK (hum) | 70 | 2 |
ASK1 | 95 | 1 |
Aurora A | 88 | 3 |
Aurora B | 63 | 8 |
BRK | 88 | 6 |
BRSK1 | 85 | 8 |
BRSK2 | 82 | 4 |
BTK | 98 | 8 |
CAMK1 | 104 | 1 |
CAMKK beta | 94 | 4 |
CDK2-Cyclin A | 75 | 4 |
CDK9-Cyclin T1 | 89 | 0 |
CHK1 | 67 | 0 |
CHK2 | 82 | 0 |
CK1 delta | 86 | 8 |
CK1 gamma 2 | 96 | 0 |
CK2 | 98 | 3 |
CLK2 | 95 | 1 |
CSK | 88 | 4 |
DAPK1 | 94 | 5 |
DDR2 | 95 | 11 |
DYRK1A | 95 | 7 |
DYRK2 | 105 | 9 |
DYRK3 | 72 | 0 |
EF2K | 120 | 1 |
EIF2AK3 | 69 | 17 |
EPH-A2 | 97 | 5 |
EPH-A4 | 97 | 7 |
EPH-B1 | 97 | 6 |
EPH-B2 | 100 | 5 |
EPH-B3 | 100 | 1 |
EPH-B4 | 89 | 0 |
ERK1 | 86 | 2 |
ERK2 | 91 | 4 |
ERK5 | 107 | 14 |
ERK8 | 102 | 9 |
FGF-R1 | 90 | 10 |
GCK | 93 | 9 |
GSK3 beta | 88 | 3 |
HER4 | 102 | 2 |
HIPK1 | 101 | 8 |
HIPK2 | 111 | 2 |
HIPK3 | 108 | 7 |
IGF-1R | 88 | 2 |
IKK beta | 98 | 2 |
IKK epsilon | 105 | 6 |
IR | 102 | 19 |
IRAK1 | 100 | 3 |
IRAK4 | 104 | 7 |
IRR | 88 | 6 |
JAK2 | 104 | 0 |
JNK1 | 90 | 1 |
JNK2 | 93 | 5 |
JNK3 | 97 | 0 |
Lck | 72 | 3 |
LKB1 | 76 | 1 |
MAP4K3 | 93 | 8 |
MAP4K5 | 105 | 14 |
MAPKAP-K2 | 98 | 9 |
MAPKAP-K3 | 104 | 0 |
MARK1 | 95 | 8 |
MARK2 | 90 | 4 |
MARK3 | 67 | 3 |
MARK4 | 98 | 8 |
MEKK1 | 90 | 9 |
MELK | 42 | 0 |
MINK1 | 82 | 5 |
MKK1 | 73 | 7 |
MKK2 | 83 | 6 |
MKK6 | 86 | 2 |
MLK1 | 91 | 0 |
MLK3 | 88 | 0 |
MNK1 | 93 | 1 |
MNK2 | 97 | 1 |
MPSK1 | 99 | 6 |
MSK1 |
7
|
2 |
MST2 | 72 | 6 |
MST3 | 92 | 2 |
MST4 | 88 | 4 |
NEK2a | 102 | 7 |
NEK6 | 104 | 6 |
NUAK1 | 18 | 1 |
OSR1 | 109 | 20 |
p38 alpha MAPK | 93 | 0 |
p38 beta MAPK | 100 | 1 |
p38 delta MAPK | 98 | 3 |
p38 gamma MAPK | 101 | 1 |
PAK2 | 97 | 5 |
PAK4 | 90 | 1 |
PAK5 | 91 | 2 |
PAK6 | 93 | 0 |
PDGFRA | 98 | 6 |
PDK1 | 81 | 6 |
PHK | 66 | 3 |
PIM1 | 89 | 2 |
PIM2 | 77 | 7 |
PIM3 | 59 | 0 |
PKA |
6
|
0 |
PKB alpha | 14 | 0 |
PKB beta | 13 | 3 |
PKC alpha | 63 | 3 |
PKC gamma | 71 | 4 |
PKC zeta | 105 | 7 |
PKD1 | 64 | 7 |
PLK1 | 92 | 0 |
PRAK | 95 | 5 |
PRK2 |
6
|
2 |
RIPK2 | 92 | 11 |
ROCK 2 |
5
|
0 |
RSK1 | 24 | 0 |
RSK2 | 40 | 7 |
S6K1 |
10
|
0 |
SGK1 | 61 | 0 |
SIK2 | 84 | 0 |
SIK3 | 109 | 7 |
SmMLCK | 86 | 6 |
Src | 96 | 7 |
SRPK1 | 89 | 4 |
STK33 | 42 | 3 |
SYK | 96 | 3 |
TAK1 | 87 | 2 |
TAO1 | 87 | 2 |
TBK1 | 91 | 29 |
TESK1 | 98 | 19 |
TGFBR1 | 106 | 3 |
TIE2 | 117 | 1 |
TLK1 | 94 | 12 |
TrkA | 107 | 1 |
TSSK1 | 63 | 10 |
TTBK1 | 105 | 14 |
TTBK2 | 95 | 6 |
TTK | 75 | 0 |
ULK1 | 98 | 4 |
ULK2 | 97 | 1 |
VEGFR1 | 89 | 4 |
WNK1 | 79 | 2 |
YES1 | 99 | 2 |
ZAP70 | 107 | 3 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 101 | 4 |
AMPK | 26 | 1 |
AMPK (hum) | 14 | 6 |
ASK1 | 99 | 4 |
Aurora A | 56 | 3 |
Aurora B | 45 | 1 |
BRK | 86 | 7 |
BRSK1 | 39 | 7 |
BRSK2 | 30 | 1 |
BTK | 79 | 8 |
CAMK1 | 47 | 0 |
CAMKK beta | 85 | 6 |
CDK2-Cyclin A | 41 | 4 |
CDK9-Cyclin T1 | 65 | 1 |
CHK1 | 24 | 4 |
CHK2 | 14 | 1 |
CK1 delta | 72 | 2 |
CK1 gamma 2 | 107 | 14 |
CK2 | 102 | 9 |
CLK2 | 55 | 1 |
CSK | 99 | 4 |
DAPK1 | 44 | 2 |
DDR2 | 85 | 20 |
DYRK1A | 93 | 1 |
DYRK2 | 93 | 5 |
DYRK3 | 15 | 2 |
EF2K | 106 | 0 |
EIF2AK3 | 90 | 23 |
EPH-A2 | 76 | 4 |
EPH-A4 | 81 | 9 |
EPH-B1 | 100 | 11 |
EPH-B2 | 94 | 9 |
EPH-B3 | 72 | 5 |
EPH-B4 | 101 | 5 |
ERK1 | 81 | 4 |
ERK2 | 93 | 5 |
ERK5 | 81 | 16 |
ERK8 | 13 | 0 |
FGF-R1 | 27 | 9 |
GCK | 24 | 1 |
GSK3 beta | 91 | 5 |
HER4 | 84 | 12 |
HIPK1 | 97 | 13 |
HIPK2 | 96 | 11 |
HIPK3 | 102 | 3 |
IGF-1R | 57 | 3 |
IKK beta | 94 | 3 |
IKK epsilon | 96 | 12 |
IR | 114 | 13 |
IRAK1 | 39 | 4 |
IRAK4 | 83 | 5 |
IRR | 73 | 2 |
JAK2 | 86 | 6 |
JNK1 | 93 | 3 |
JNK2 | 99 | 4 |
JNK3 | 93 | 0 |
Lck | 77 | 7 |
LKB1 | 78 | 8 |
MAP4K3 | 49 | 8 |
MAP4K5 | 94 | 0 |
MAPKAP-K2 | 55 | 1 |
MAPKAP-K3 | 91 | 1 |
MARK1 | 62 | 8 |
MARK2 | 35 | 4 |
MARK3 | 29 | 4 |
MARK4 | 63 | 9 |
MEKK1 | 94 | 4 |
MELK | 38 | 4 |
MINK1 | 34 | 1 |
MKK1 | 54 | 3 |
MKK2 | 46 | 3 |
MKK6 | 97 | 0 |
MLK1 | 51 | 3 |
MLK3 | 70 | 1 |
MNK1 | 87 | 1 |
MNK2 | 87 | 3 |
MPSK1 | 100 | 2 |
MSK1 |
5
|
0 |
MST2 | 57 | 0 |
MST3 | 49 | 1 |
MST4 | 53 | 10 |
NEK2a | 94 | 8 |
NEK6 | 102 | 9 |
NUAK1 |
4
|
1 |
OSR1 | 97 | 2 |
p38 alpha MAPK | 100 | 5 |
p38 beta MAPK | 101 | 4 |
p38 delta MAPK | 75 | 4 |
p38 gamma MAPK | 96 | 4 |
PAK2 | 94 | 8 |
PAK4 | 65 | 1 |
PAK5 | 84 | 0 |
PAK6 | 68 | 7 |
PDGFRA | 67 | 11 |
PDK1 | 95 | 3 |
PHK | 54 | 5 |
PIM1 | 87 | 2 |
PIM2 | 105 | 4 |
PIM3 | 81 | 3 |
PKA |
1
|
0 |
PKB alpha |
5
|
2 |
PKB beta | 12 | 1 |
PKC alpha | 77 | 2 |
PKC gamma | 38 | 2 |
PKC zeta | 35 | 2 |
PKD1 | 31 | 2 |
PLK1 | 93 | 2 |
PRAK | 65 | 4 |
PRK2 |
6
|
4 |
RIPK2 | 99 | 1 |
ROCK 2 |
6
|
1 |
RSK1 |
8
|
1 |
RSK2 | 19 | 2 |
S6K1 |
3
|
0 |
SGK1 | 16 | 0 |
SIK2 | 50 | 2 |
SIK3 | 71 | 0 |
SmMLCK | 70 | 6 |
Src | 94 | 6 |
SRPK1 | 91 | 1 |
STK33 | 11 | 0 |
SYK | 94 | 11 |
TAK1 | 67 | 2 |
TAO1 | 65 | 4 |
TBK1 | 88 | 6 |
TESK1 | 93 | 7 |
TGFBR1 | 113 | 6 |
TIE2 | 91 | 10 |
TLK1 | 88 | 15 |
TrkA | 83 | 12 |
TSSK1 | 66 | 20 |
TTBK1 | 110 | 25 |
TTBK2 | 100 | 4 |
TTK | 106 | 2 |
ULK1 | 71 | 5 |
ULK2 | 71 | 9 |
VEGFR1 | 13 | 1 |
WNK1 | 85 | 17 |
YES1 | 85 | 5 |
ZAP70 | 124 | 9 |