This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.
We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.
If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.
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| Inhibitor | Brutto | MW | Action | Reference | Screen Conc | % Activity Remaining |
|---|---|---|---|---|---|---|
| Amgen TBK 1 inhibitor (Compound II) | C28H35N7O4 | 533.62 | TBK1 |
Ou Y.H. (2011) Molecular Cell 41 458-470 |
0.10 | 54 |
| Amgen-NIK-28 | C20H20N4O | 332.40 | NIK |
Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244 |
0.10 | 98 |
| Amgen-NIK-28 | C20H20N4O | 332.40 | NIK |
Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244 |
1.00 | 103 |
| Amlexanox | C16H14N2O4 | 298.29 | TBK1, IKKe |
|
1.00 | 98 |
| Amlexanox | C16H14N2O4 | 298.29 | TBK1, IKKe |
|
10.00 | 109 |
| AX 20017 | C13H16N2O2S | 264.34 | PknG |
Walburger A (2004) Science 304 1800-1804 |
1.00 | 94 |
| AX 20017 | C13H16N2O2S | 264.34 | PknG |
Walburger A (2004) Science 304 1800-1804 |
10.00 | 80 |
| BAY 61-3606 | C20H18N6O3 · xHCl · yH2O | 390.40 | Syk |
Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181 |
10.00 | 82 |
| BAY 61-3606 | C20H18N6O3 · xHCl · yH2O | 390.40 | Syk |
Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181 |
1.00 | 79 |
| BI 2536 | C28H39N7O3 | 521.65 | PLK1 |
Steegmaier M. (2007) Current Biology 17 316-322 |
1.00 | 94 |