Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

5.00 111
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

1.00 126
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

1.00 126
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

5.00 111
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


0.10 81
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


10.00 64
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


1.00 57
Y-27632   C14H21N3O • 2HCl • H2O 338.30 ROCK Watanabe K. (2007) Nature Biotech. 25 681
Chitaley K. (2001) Nat. Med. 7 119

10.00 96
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


10.00 35
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


1.00 79