Inhibitor | AG490  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	94	11
ASK1	102	7
Aurora A	99	1
Aurora B	77	2
BRSK1	100	5
BRSK2	94	12
BTK	84	3
CAMK1	113	5
CAMKK beta	106	4
CDK2-Cyclin A	101	8
CHK1	83	10
CHK2	85	12
CK1 delta	90	5
CK2	114	1
CLK2	90	13
CSK	85	0
DAPK1	85	10
DYRK1A	74	1
DYRK2	71	0
DYRK3	87	0
EF2K	82	1
EPH-A2	89	5
EPH-A4	99	5
EPH-B1	91	7
EPH-B2	91	6
EPH-B3	86	9
EPH-B4	104	9
ERK1	82	9
ERK2	106	4
ERK8	102	6
FGF-R1	102	11
GCK	92	6
GSK3 beta	88	6
HER4	88	1
HIPK1	79	6
HIPK2	106	4
HIPK3	99	2
IGF-1R	101	1
IKK beta	97	4
IKK epsilon	91	0
IR	106	2
IRAK4	86	4
IRR	91	6
JAK2	104	6
JNK1	89	15
JNK2	93	0
JNK3	109	7
Lck	105	1
LKB1	80	3
MAPKAP-K2	87	7
MAPKAP-K3	86	9
MARK1	96	3
MARK2	75	4
MARK3	97	3
MARK4	90	8
MEKK1	111	6
MELK	78	1
MINK1	79	3
MKK1	82	10
MKK2	88	9
MKK6	90	5
MLK1	72	4
MLK3	77	1
MNK1	112	0
MNK2	106	5
MSK1	55	2
MST2	84	1
MST4	103	2
NEK2a	79	8
NEK6	101	12
NUAK1	84	15
p38 alpha MAPK	75	4
p38 beta MAPK	86	4
p38 delta MAPK	96	9
p38 gamma MAPK	116	5
PAK2	100	9
PAK4	76	3
PAK5	90	2
PAK6	87	8
PDK1	92	12
PHK	102	7
PIM1	84	7
PIM2	104	13
PIM3	70	6
PKA	91	1
PKB alpha	99	3
PKB beta	71	7
PKC alpha	98	1
PKC zeta	107	4
PKD1	90	12
PLK1	92	7
PRAK	92	1
PRK2	83	3
RIPK2	100	4
ROCK 2	84	9
RSK1	78	4
RSK2	84	8
S6K1	89	2
SGK1	54	4
SmMLCK	80	1
Src	74	3
SRPK1	85	12
SYK	76	1
TAK1	84	1
TAO1	90	7
TBK1	84	6
TrkA	82	10
TTK	81	0
VEGFR1	83	15
YES1	106	0

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	87	9
ASK1	105	2
Aurora A	64	3
Aurora B	64	3
BRSK1	85	5
BRSK2	75	0
BTK	85	13
CAMK1	106	4
CAMKK beta	109	7
CDK2-Cyclin A	111	11
CHK1	119	15
CHK2	52	6
CK1 delta	88	5
CK2	99	5
CLK2	102	5
CSK	95	6
DAPK1	94	11
DYRK1A	24	2
DYRK2	50	5
DYRK3	44	5
EF2K	91	5
EPH-A2	92	5
EPH-A4	94	10
EPH-B1	93	5
EPH-B2	87	7
EPH-B3	117	15
EPH-B4	97	6
ERK1	83	13
ERK2	105	9
ERK8	83	5
FGF-R1	93	4
GCK	102	7
GSK3 beta	78	3
HER4	62	11
HIPK1	85	1
HIPK2	83	0
HIPK3	103	1
IGF-1R	119	5
IKK beta	89	3
IKK epsilon	88	0
IR	115	6
IRAK4	103	1
IRR	58	1
JAK2	98	4
JNK1	88	5
JNK2	99	6
JNK3	91	7
Lck	97	2
LKB1	94	11
MAPKAP-K2	112	10
MAPKAP-K3	122	6
MARK1	95	5
MARK2	77	3
MARK3	70	12
MARK4	98	9
MEKK1	99	6
MELK	79	4
MINK1	93	6
MKK1	82	9
MKK2	109	2
MKK6	93	12
MLK1	52	5
MLK3	65	6
MNK1	98	2
MNK2	102	3
MSK1	28	5
MST2	101	2
MST4	86	0
NEK2a	65	2
NEK6	95	13
NUAK1	58	4
p38 alpha MAPK	82	3
p38 beta MAPK	95	0
p38 delta MAPK	99	3
p38 gamma MAPK	129	1
PAK2	88	11
PAK4	89	10
PAK5	99	5
PAK6	106	4
PDK1	103	6
PHK	98	11
PIM1	53	0
PIM2	93	10
PIM3	25	1
PKA	98	11
PKB alpha	117	4
PKB beta	52	7
PKC alpha	107	7
PKC zeta	105	5
PKD1	92	3
PLK1	119	4
PRAK	77	4
PRK2	91	8
RIPK2	96	11
ROCK 2	78	4
RSK1	85	11
RSK2	109	4
S6K1	96	4
SGK1	18	2
SmMLCK	94	15
Src	56	1
SRPK1	92	2
SYK	86	9
TAK1	116	1
TAO1	125	10
TBK1	107	2
TrkA	85	8
TTK	76	1
VEGFR1	86	14
YES1	72	4