Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
RO-31-8220   C25H23N5O2S • CH4O3S 553.70 PKC Trapp J. (2006) J. Med. Chem. 49 7307-16
Powell D.J. (2003) Mol. Cell Biol. 23 7794

1.00 5
RO-3306   C₁₈H₁₃N₃OS₂ 351.50 Cdk1 Vassilev, L.T. (2006) Proc. Natl. Acad. Sci. USA 103 10660


1.00 59
RO-3306   C₁₈H₁₃N₃OS₂ 351.50 Cdk1 Vassilev, L.T. (2006) Proc. Natl. Acad. Sci. USA 103 10660


10.00 22
Roscovitine   C19H26N6O 354.50 CDK De Azevedo W.F. (1997) Eur. J. Biochem. 243 518
Meijer L. (1997) Eur. J. Biochem. 243 527

10.00 95
Ruxolitinib   C17H18N6 306.37 JAKs Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-6…

WO2008157208
1.00 74
Ruxolitinib   C17H18N6 306.37 JAKs Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-6…

WO2008157208
0.10 85
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488


1.00 94
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488


0.10 106
SB-431542   C22H16N4O3 · xH2O 384.39 ALK Inman et al (2002) Mol.Pharmacol. 62 65


1.00 95
SB-431542   C22H16N4O3 · xH2O 384.39 ALK Inman et al (2002) Mol.Pharmacol. 62 65


0.10 99