Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
PP3 C11H9N5 211.22 Src Hou (2007) Neurosci Lett 420 235


 10.00 114
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639


 1.00 52
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639


 0.10 56
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639


 10.00 19
PRT062607   C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387


 0.10 93
PRT062607   C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387


 10.00 51
Purvalanol A   C19H25ClN6O 388.90 cyclin-dependent kinases Gray N.S. (1998) Science 281 533


0.10 81
Purvalanol A   C19H25ClN6O 388.90 cyclin-dependent kinases Gray N.S. (1998) Science 281 533


1.00 70
Purvalanol B   C20H25ClN6O3 432.90 CDK
WO1999007705
 1.00 43
Purvalanol B   C20H25ClN6O3 432.90 CDK
WO1999007705
 0.10 90