Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


10.00 112
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11


100.00 89
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11


250.00 89
MK-2206   C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43


10.00 53
MK-2206   C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43


0.10 88
MK-2206   C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43


1.00 81
MLi-2   C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 35…

WO2014134774
1.00 115
MLi-2   C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 35…

WO2014134774
10.00 109
MLN120B   C19H17Cl3N4O2 439.72 IKKb Nagashima K. Fraser C.C. (2006) Blood 107 4266-4273
Catley M.C. Newton R. (2006) Mol.Pharmacol. 70 697-705

10.00 74
MLN120B   C19H17Cl3N4O2 439.72 IKKb Nagashima K. Fraser C.C. (2006) Blood 107 4266-4273
Catley M.C. Newton R. (2006) Mol.Pharmacol. 70 697-705

30.00 20