Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Necrostatin-1 (Nec-1)   C13H13N3OS 259.33 RIP Degterev A. Hitomi J. (2008) Nature Chemical Biology 4 313-321

WO2013013826
10.00 88
Necrostatin-1 (Nec-1)   C13H13N3OS 259.33 RIP Degterev A. Hitomi J. (2008) Nature Chemical Biology 4 313-321

WO2013013826
1.00 91
Nectrostatin-1 (Nec-1 inactive analog)   C12H11N3OS 245.30 RIP Degterev A. Hitomi J. (2008) Nature Chemical Biology 4 313-321

WO2007075772
10.00 96
Nectrostatin-1 (Nec-1 inactive analog)   C12H11N3OS 245.30 RIP Degterev A. Hitomi J. (2008) Nature Chemical Biology 4 313-321

WO2007075772
1.00 89
NG-25 C29H30F3N5O2 537.58 TAK1 Dzamko N (2012) PLoS ONE 7(6) e39132 10 1371
Eduardo Pauls (2012) Journal of Biological Chemistry 287 23 19216-19228

0.10 70
NG-25 C29H30F3N5O2 537.58 TAK1 Dzamko N (2012) PLoS ONE 7(6) e39132 10 1371
Eduardo Pauls (2012) Journal of Biological Chemistry 287 23 19216-19228

10.00 3
NG-25 C29H30F3N5O2 537.58 TAK1 Dzamko N (2012) PLoS ONE 7(6) e39132 10 1371
Eduardo Pauls (2012) Journal of Biological Chemistry 287 23 19216-19228

1.00 15
NIK-Novartis-T1-7   C18H14N6OS 362.41 NIK
US20120214762
1.00 92
NIK-Novartis-T1-7   C18H14N6OS 362.41 NIK
US20120214762
0.10 120
Novartis 12a (PKD1)   C23H29F3N6O3 494.51 PKD1 Meredith E.L. (2010) J.Med.Chem. 53 5422-5438


0.10 95