Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Sulfasalazine   C18H14N4O5S 398.39 glutathione-S-transferase Liptay S. (1999) Br. J. Pharmacol. 128 1361
Volin M.V. (1999) Arthritis Rheum. 42 1927

1.00 112
TG003   C13H15NO2S 249.33 Cdc2-like kinase Muraki M. (2004) J. Biol. Chem. 279 24246-24254


 1.00 82
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 106
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 43
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 10.00 3
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 1.00 20
1 NM-PP1 (PP1 Analog II)   C20H21N5 331.40 Src Ira G. (2004) Nature 431 1011
Papa F.R. (2003) Science 302 1533
WO2000042042
 10.00 7
1 NM-PP1 (PP1 Analog II)   C20H21N5 331.40 Src Ira G. (2004) Nature 431 1011
Papa F.R. (2003) Science 302 1533
WO2000042042
 1.00 29
2-Aminopurine   C5H5N5 135.13 PKR

100.00 73
A-443654   C24H23ON5x2HCl 470.39 Akt1 Shi Y. (2005) Neoplasia 7 992-1000.

WO2007106884
 0.01 91