Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


 10.00 91
CGP-57380   C11H9FN6 244.23 MNK Knauf U. (2001) Mol. Cell. Biol. 21 5500-5511
Proud C.G. (2005) Immunity 23 177-189
WO2010055072
 1.00 57
CGP-57380   C11H9FN6 244.23 MNK Knauf U. (2001) Mol. Cell. Biol. 21 5500-5511
Proud C.G. (2005) Immunity 23 177-189
WO2010055072
 10.00 41
CGP-57380 analog (SHN-093)   C12H11FN6 258.25 MNK Proud C.G. (2005) Immunity 23 177-189


 10.00 98
QNZ   C22H20N4O 356.40 NF-κB

10.00 88
SP600125 (JNK Inhibitor II, SAPK Inhibitor II)   C14H8N2O 220.20 JNK Shin M. Boyd Y.D. (2002) Biochim. Biophys. Acta 1589 311
Bennett B.L. (2001) Proc. Natl. Acad. Sci. USA 98 13681

1.00 27
Tenovin-6   C25H34N4O2S 454.60

10.00 88
2-Aminopurine   C5H5N5 135.13 PKR

100.00 43
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244


 0.10 81
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244


 1.00 77