Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


 10.00 96
CAY10576   C22H19N3O5S2 469.50 IKKe

1.00 97
CGP-57380   C11H9FN6 244.23 MNK Knauf U. (2001) Mol. Cell. Biol. 21 5500-5511
Proud C.G. (2005) Immunity 23 177-189
WO2010055072
 1.00 90
PP2   C15H16ClN5 301.77 Src Kirihara T. (2013) Exp Eye Res. S0014

WO2006068760
 1.00 82
PP3 C11H9N5 211.22 Src Hou (2007) Neurosci Lett 420 235


 20.00 96
SGK1-Sanofi-ex.290-R   C24H25ClN6O5S 545.01 SGK1
WO2014140065
 1.00 77
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 88
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 119
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 1.00 94
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 10.00 55