Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


 1.00 105
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


 10.00 104
Celastrol   C29H38O4 450.60 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13

WO2007117466
 5.00 91
NIK-Novartis-T1-7   C18H14N6OS 362.41 NIK
US20120214762
 1.00 114
Novartis 12a (PKD1)   C23H29F3N6O3 494.51 PKD1 Meredith E.L. (2010) J.Med.Chem. 53 5422-5438


 1.00 106
PD 0325901   C16H14F3IN2O4 482.19 MEK1 Bain J. (2007) Biochem J. 408 297–315.
Barrett SD. (2008) Bioorg. Med. Chem. Lett. 18 6501-6504.
WO2002006213
 1.00 101
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869
Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

1.00 102
Ubiquitin E1 Inhibitor (PYR-41)   C17H13N3O7 • 3H2O 425.40 Ubiquitin-E1 Yang Y (2007) Cancer Res. 67 9472


 10.00 79
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 84
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 86