Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
GF 109203X (Go 6850)   C25H24N4O2 412.50 PKC Hers I. (1999) FEBS Lett. 460 433
Ku W.-C. (1997) Biochem. Biophys. Res. Commun. 241 730
US7067144
10.00 4
Imatinib   C29H31N7O 493.60 BCR-ABL, c-KIT, PDGFR Druker B. J. (2000) J. Clin. Invest. 105 3-7

WO2006039533
1.00 93
Imatinib   C29H31N7O 493.60 BCR-ABL, c-KIT, PDGFR Druker B. J. (2000) J. Clin. Invest. 105 3-7

WO2006039533
10.00 95
Gö 7874   C27H26N4O4 • HCl 507.00 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55

US20080153903
0.10 64
Gö 6976   C24H18N4O 378.40 PKC Gschwendt M. (1996) FEBS Lett. 392 77
Wenzel-Seifert K. (1994) Biochem. Biophys. Res. Commun. 200 1536
WO2003009809
0.10 16
Gö 7874   C27H26N4O4 • HCl 507.00 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55

US20080153903
1.00 19
Gö 7874   C27H26N4O4 • HCl 507.00 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55

US20080153903
10.00 24
GSK2334470   C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69


10.00 44
GSK2334470   C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69


0.01 107
GSK2334470   C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69


0.10 111