Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Chelerythrine Chloride   C21H18NO4Cl 383.80 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209
Jarvis W.D. (1994) Cancer Res. 54 1707
WO2003077917
 1.00 76
Novartis 12a (PKD1)   C23H29F3N6O3 494.51 PKD1 Meredith E.L. (2010) J.Med.Chem. 53 5422-5438


 0.10 97
Sodium valproate   C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734
Kostrouchova (2007) Folia Biologica 53 37

10.00 101
Sphingosine Kinase Inhibitor (SKI II)   C15H11ClN2OS 339.20 SphK1 French (2003) Cancer Res. 63 5962.
French (2006) J.Pharmacol.Exp.Ther. 318 596

1.00 98
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319
Blake R.A. (2000) Mol. Cell. Biol. 20 9018

1.00 75
SYK Inhibitor II   C14H15F3N6O • 2HCl•2H2O 449.30 SYK Hisamichi H. (2005) Bioorg. Med. Chem. 13 4936


 1.00 50
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 87
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 100
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 10.00 57
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 1.00 94