This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.
We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.
If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.
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| Inhibitor | Brutto | MW | Action | Reference | Screen Conc | % Activity Remaining |
|---|---|---|---|---|---|---|
| BX-912 | C20H23BrN8O | 471.35 | PDK |
Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74 |
0.10 | 101 |
| Caffeine | C8H10N4O2 | 194.19 | ATM |
Islam M.S. (1998) Proc. Natl. Acad. Sci. USA 95 6145-6150 |
1.00 | 102 |
| Caffeine | C8H10N4O2 | 194.19 | ATM |
Islam M.S. (1998) Proc. Natl. Acad. Sci. USA 95 6145-6150 |
0.10 | 107 |
| CAY10576 | C22H19N3O5S2 | 469.50 | IKKe |
|
10.00 | 93 |
| CAY10576 | C22H19N3O5S2 | 469.50 | IKKe |
|
1.00 | 102 |
| CCT250862 | NEK |
|
1.00 | 55 | ||
| Celastrol | C29H38O4 | 450.60 | hsp90, ampk |
Kim JH. Cell Signal. (2013) 805-13 WO2007117466 |
5.00 | 118 |
| Celastrol | C29H38O4 | 450.60 | hsp90, ampk |
Kim JH. Cell Signal. (2013) 805-13 WO2007117466 |
1.00 | 102 |
| CGP-57380 | C11H9FN6 | 244.23 | MNK |
Knauf U. (2001) Mol. Cell. Biol. 21 5500-5511 Proud C.G. (2005) Immunity 23 177-189 WO2010055072 |
1.00 | 91 |
| CGP-57380 analog (SHN-093) | C12H11FN6 | 258.25 | MNK |
Proud C.G. (2005) Immunity 23 177-189 |
1.00 | 102 |