Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

5.00 103
LFM-A13   C11H8Br2N2O2 360.00 BTK Vassilev J.Biol.Chem. 274 1646
Mahajan et al J.Biol.Chem. 274 9587

10.00 73
PCI-32765 (Ibrutinib)   C25H24N6O2 440.50 Btk Honigberg L.A. (2010) Proc Natl Acad Sci 107 13075-13080


 1.00 117
PD 0325901   C16H14F3IN2O4 482.19 MEK1 Bain J. (2007) Biochem J. 408 297–315.
Barrett SD. (2008) Bioorg. Med. Chem. Lett. 18 6501-6504.
WO2002006213
 1.00 111
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 100
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 107
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 10.00 46
1 NA-PP1 (PP1 Analog)   C19H19N5 317.40 Src Bishop A. C. (2000) Nature 407 395
Bishop A.C. (1999) J. Am. Chem. Soc. 121 627
WO2003082341
 1.00 81
1 NM-PP1 (PP1 Analog II)   C20H21N5 331.40 Src Ira G. (2004) Nature 431 1011
Papa F.R. (2003) Science 302 1533
WO2000042042
 1.00 78
1 NM-PP1 (PP1 Analog II)   C20H21N5 331.40 Src Ira G. (2004) Nature 431 1011
Papa F.R. (2003) Science 302 1533
WO2000042042
 10.00 69