Inhibitor | AG1478 (Tyrphostin)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
AG1478 (Tyrphostin)   C16H14ClN3O2 315.75 153436-53-4 2051 EGFR Osherov N. (1994) A. Eur. J. Biochem. 225 1047 https://pubmed.ncbi.nlm.nih.gov/[pmid2]

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 80 8
ASK1 104 1
Aurora A 82 6
Aurora B 53 3
BRSK1 74 9
BRSK2 79 4
BTK 69 0
CAMK1 106 6
CAMKK beta 97 1
CDK2-Cyclin A 112 7
CHK1 81 4
CHK2 81 5
CK1 delta 100 5
CK2 99 0
CLK2 95 3
CSK 86 9
DAPK1 88 2
DYRK1A 90 5
DYRK2 74 3
DYRK3 76 6
EF2K 88 3
EPH-A2 77 1
EPH-A4 58 1
EPH-B1 107 13
EPH-B2 57 10
EPH-B3 63 11
EPH-B4 67 2
ERK1 84 11
ERK2 94 5
ERK8 96 9
FGF-R1 75 1
GCK 82 2
GSK3 beta 90 13
HER4 25 0
HIPK1 93 7
HIPK2 100 4
HIPK3 101 0
IGF-1R 104 13
IKK beta 90 4
IKK epsilon 82 4
IR 105 5
IRAK4 38 0
IRR 93 5
JAK2 61 1
JNK1 100 0
JNK2 79 3
JNK3 76 6
Lck 54 2
LKB1 93 11
MAPKAP-K2 81 6
MAPKAP-K3 88 2
MARK1 101 4
MARK2 79 6
MARK3 83 3
MARK4 104 14
MEKK1 88 5
MELK 91 7
MINK1 62 4
MKK1 94 1
MKK2 84 7
MKK6 103 4
MLK1 63 3
MLK3 53 5
MNK1 44 3
MNK2 47 4
MSK1 87 7
MST2 76 0
MST4 100 12
NEK2a 86 6
NEK6 90 2
NUAK1 80 5
p38 alpha MAPK 37 2
p38 beta MAPK 68 10
p38 delta MAPK 99 4
p38 gamma MAPK 98 3
PAK2 101 11
PAK4 98 5
PAK5 90 0
PAK6 99 4
PDK1 92 5
PHK 85 3
PIM1 79 14
PIM2 102 2
PIM3 75 12
PKA 97 15
PKB alpha 102 9
PKB beta 69 11
PKC alpha 79 7
PKC zeta 104 6
PKD1 87 3
PLK1 104 3
PRAK 87 0
PRK2 86 3
RIPK2
10
1
ROCK 2 86 2
RSK1 82 2
RSK2 83 7
S6K1 82 2
SGK1 106 3
SmMLCK 49 0
Src 39 1
SRPK1 98 5
SYK 110 3
TAK1 91 7
TAO1 93 8
TBK1 83 1
TrkA 65 9
TTK 83 2
VEGFR1 31 0
YES1 42 4
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 68 1
Aurora A 15 0
Aurora B 46 5
BRSK1 40 2
BRSK2 41 3
BTK 15 0
CAMK1 94 1
CAMKK beta 52 2
CDK2-Cyclin A 91 8
CHK1 78 4
CHK2 23 0
CK1 delta 65 11
CK2 90 2
CSK 57 13
DYRK1A 45 2
DYRK2 33 3
DYRK3 23 3
EF2K 113 6
EPH-A2 18 0
EPH-B3 63 0
ERK1 75 0
ERK2 39 6
ERK8 61 9
FGF-R1 44 5
GCK 43 2
GSK3 beta 75 5
HER4
3
1
HIPK1 120 59
HIPK2 76 2
HIPK3 96 2
IGF-1R 95 7
IKK beta 89 0
IKK epsilon 67 3
IR 81 2
IRAK4 11 0
IRR 78 0
JNK1 105 7
JNK2 78 7
JNK3 73 8
Lck 34 0
LKB1 99 19
MAPKAP-K2 89 4
MAPKAP-K3 98 4
MARK2 102 3
MARK3 61 0
MARK4 79 4
MELK 55 0
MINK1 14 0
MKK1 52 0
MLK1 24 0
MLK3 75 14
MNK1
7
0
MNK2 36 5
MSK1 96 2
MST2 35 0
MST4 62 21
NEK2a 82 3
NEK6 100 1
NUAK1 39 4
p38 alpha MAPK 12 1
p38 beta MAPK 38 0
p38 delta MAPK 97 6
p38 gamma MAPK 105 9
PAK2 85 0
PAK4 87 6
PAK5 81 2
PAK6 98 1
PDK1 79 5
PHK 23 3
PIM1 40 5
PIM2 96 3
PIM3 29 4
PKA 107 7
PKB alpha 86 10
PKB beta 93 10
PKC alpha 74 3
PKC zeta 106 7
PKD1 32 2
PLK1 74 10
PRAK 88 12
PRK2 111 3
RIPK2 14 3
ROCK 2 61 9
RSK1 74 14
RSK2 82 1
S6K1 86 1
SGK1 83 6
SmMLCK 14 0
Src
8
1
SRPK1 98 2
SYK 107 3
TBK1 40 7
TTK 79 1
VEGFR1
5
0
YES1
5
0