Inhibitor | A-83-01  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
A-83-01   C25H19N5S 421.52 909910-43-6 16218924 ALK5 Tojo (2005) Cancer.Sci. 96 791 https://pubmed.ncbi.nlm.nih.gov/[pmid2]

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 99 3
Aurora A 120 7
Aurora B 98 5
BRSK1 110 12
BRSK2 117 6
BTK 110 5
CAMK1 103 18
CAMKK beta 100 10
CDK2-Cyclin A 93 4
CHK1 107 10
CHK2 115 10
CK1 delta 90 8
CK2 102 0
CLK2 106 10
CSK 97 2
DAPK1 94 3
DYRK1A 109 11
DYRK2 100 0
DYRK3 102 8
EF2K 102 4
EPH-A2 105 5
EPH-A4 108 1
EPH-B2 113 2
EPH-B3 112 6
EPH-B4 93 2
ERK1 105 15
ERK2 104 11
ERK8 108 16
FGF-R1 64 3
GCK 98 3
GSK3 beta 99 1
HER4 104 1
HIPK1 96 4
HIPK2 104 8
HIPK3 105 8
IGF-1R 97 5
IKK beta 107 1
IKK epsilon 112 5
IR 108 7
IRAK4 101 3
IRR 98 5
JAK2 107 18
JNK1 111 3
JNK2 105 6
JNK3 119 3
Lck 105 7
LKB1 101 5
MAPKAP-K2 117 3
MAPKAP-K3 107 3
MARK1 107 3
MARK2 121 8
MARK3 101 4
MARK4 98 2
MEKK1 130 15
MELK 111 2
MINK1 66 2
MKK1 111 20
MLK1 96 7
MLK3 104 2
MNK1 103 1
MNK2 81 5
MSK1 110 6
MST2 107 0
MST4 95 2
NEK2a 109 8
NEK6 107 3
NUAK1 96 10
p38 alpha MAPK 56 1
p38 beta MAPK 89 15
p38 delta MAPK 91 20
p38 gamma MAPK 102 13
PAK2 111 17
PAK4 89 6
PAK5 107 2
PAK6 111 12
PDK1 103 8
PHK 100 11
PIM1 105 3
PIM2 97 4
PIM3 91 4
PKA 109 2
PKB alpha 102 5
PKB beta 108 3
PKC alpha 97 5
PKC zeta 98 0
PKD1 80 1
PLK1 99 11
PRAK 113 7
PRK2 105 12
RIPK2 26 6
ROCK 2 96 2
RSK1 110 6
RSK2 126 3
S6K1 108 2
SGK1 107 1
SmMLCK 104 8
Src 102 1
SRPK1 101 7
SYK 109 10
TAK1 99 9
TBK1 102 7
TrkA 118 2
TTK 113 0
VEGFR1 27 0
YES1 106 4
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 82 4
Aurora A 107 3
Aurora B 102 1
BRSK1 95 7
BRSK2 92 14
BTK 104 5
CAMK1 107 13
CAMKK beta 104 2
CDK2-Cyclin A 102 11
CHK1 105 3
CHK2 110 6
CK1 delta 46 5
CK2 104 11
CLK2 98 0
CSK 93 1
DAPK1 90 2
DYRK1A 104 1
DYRK2 95 7
DYRK3 93 4
EF2K 100 3
EPH-A2 92 14
EPH-A4 98 3
EPH-B2 95 5
EPH-B3 104 0
EPH-B4 93 19
ERK1 100 5
ERK2 94 2
ERK8 93 4
FGF-R1 37 2
GCK 68 7
GSK3 beta 79 4
HER4 82 15
HIPK1 98 11
HIPK2 95 12
HIPK3 99 1
IGF-1R 103 11
IKK beta 100 12
IKK epsilon 106 0
IR 94 6
IRAK4 99 5
IRR 103 3
JAK2 93 4
JNK1 101 4
JNK2 90 7
JNK3 99 7
Lck 62 3
LKB1 99 11
MAPKAP-K2 108 2
MAPKAP-K3 97 4
MARK1 113 7
MARK2 110 9
MARK3 98 7
MARK4 87 2
MEKK1 111 0
MELK 105 3
MINK1 13 2
MKK1 98 1
MLK1 86 2
MLK3 107 4
MNK1 93 1
MNK2 91 2
MSK1 101 0
MST2 100 6
MST4 99 1
NEK2a 92 3
NEK6 100 5
NUAK1 84 4
p38 alpha MAPK 16 1
p38 beta MAPK 61 7
p38 delta MAPK 94 4
p38 gamma MAPK 88 8
PAK2 101 12
PAK4 93 4
PAK5 102 4
PAK6 113 19
PDK1 88 0
PHK 112 4
PIM1 97 4
PIM2 94 3
PIM3 117 11
PKA 99 5
PKB alpha 106 9
PKB beta 96 5
PKC alpha 102 7
PKC zeta 100 3
PKD1 32 9
PLK1 106 7
PRAK 99 16
PRK2 91 3
RIPK2
9
3
ROCK 2 104 2
RSK1 95 2
RSK2 109 8
S6K1 105 13
SGK1 103 14
SmMLCK 89 1
Src 75 1
SRPK1 84 1
SYK 106 2
TAK1 81 9
TBK1 106 1
TrkA 99 11
TTK 98 6
VEGFR1
8
1
YES1 70 5