Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


1.00 75
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


10.00 88
Crenolanib   C26H29N5O2 443.50 FLT3 Smith CC (2014 )Proc Natl Acad Sci U S A Apr 8 111(14) 5319-24


1.00 80
Curcumin   C21H20O6 368.40 Inhibits EGF receptor Cui L. (2007) Antimicrob. Agents Chemother. 51 488
Salvioli S. (2007) eCAM 4 181
WO2000070949
1.00 39
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381
A. Zhao (1999) J. Antibiot. 52 1086

0.10 108
NG-25 C29H30F3N5O2 537.58 TAK1 Dzamko N (2012) PLoS ONE 7(6) e39132 10 1371
Eduardo Pauls (2012) Journal of Biological Chemistry 287 23 19216-19228

1.00 91
NIK-Novartis-T1-7   C18H14N6OS 362.41 NIK
US20120214762
0.10 119
PRT062607   C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387


10.00 11
SB-747651A C16H22N8O 342.40 Naqvi (2012) Biochem. J. 441 (347–357)


0.10 71
Ubiquitin E1 Inhibitor (PYR-41)   C17H13N3O7 • 3H2O 425.40 Ubiquitin-E1 Yang Y (2007) Cancer Res. 67 9472


10.00 106