Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


10.00 18
Y-27632   C14H21N3O • 2HCl • H2O 338.30 ROCK Watanabe K. (2007) Nature Biotech. 25 681
Chitaley K. (2001) Nat. Med. 7 119

10.00 94
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


1.00 77
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


10.00 26
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


1.00 100
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


10.00 87
CGP-57380 analog (SHN-093)   C12H11FN6 258.25 MNK Proud C.G. (2005) Immunity 23 177-189


10.00 70
LFM-A13   C11H8Br2N2O2 360.00 BTK Vassilev J.Biol.Chem. 274 1646
Mahajan et al J.Biol.Chem. 274 9587

10.00 85
NG-25 C29H30F3N5O2 537.58 TAK1 Dzamko N (2012) PLoS ONE 7(6) e39132 10 1371
Eduardo Pauls (2012) Journal of Biological Chemistry 287 23 19216-19228

0.10 106
Novartis 12a (PKD1)   C23H29F3N6O3 494.51 PKD1 Meredith E.L. (2010) J.Med.Chem. 53 5422-5438


10.00 4