Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
KN93   C26H29CIN2O4S 501.00 CaMKII Fan G.H. (1999) Mol. Pharmacol. 56 39
Tombes R.M. (1995) Cell Growth Differ. 6 1063
WO2009042906
 1.00 87
KU 0063794   C25H31N5O4 465.54 mTOR Juan M. García-Martínez (2009) Biochem J. 421 29–42


 1.00 97
KU 0063794   C25H31N5O4 465.54 mTOR Juan M. García-Martínez (2009) Biochem J. 421 29–42


 10.00 89
KU 55933   C21H17NO3S2 395.49 ATM kinase Hickson (2004) Cancer Res. 64 9152


 10.00 78
KU 55933   C21H17NO3S2 395.49 ATM kinase Hickson (2004) Cancer Res. 64 9152


 0.01 109
KU 55933   C21H17NO3S2 395.49 ATM kinase Hickson (2004) Cancer Res. 64 9152


 1.00 105
KU 55933   C21H17NO3S2 395.49 ATM kinase Hickson (2004) Cancer Res. 64 9152


 0.10 90
KU55933   C21H17NO3S2 395.49 ATM Li Y. (2010) Mol. Cancer Ther. 2010 Jan. 9(1) 113-25


 0.10 92
KU55933   C21H17NO3S2 395.49 ATM Li Y. (2010) Mol. Cancer Ther. 2010 Jan. 9(1) 113-25


 1.00 81
LDN-193189   C25H22N6 406.49 BMP Yu (2008) Nat. Chem. Biol. 4 33–41
Cuny (2008) Bioorg. Med. Chem. Lett. 18 4388–4392

10.00 26