Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244


 1.00 90
Amlexanox   C16H14N2O4 298.29 TBK1, IKKe

10.00 22
Amlexanox   C16H14N2O4 298.29 TBK1, IKKe

1.00 73
ARA014418   C12H12N4O4S 308.30 GSK3 Noble W. (2005) Proc. Natl. Acad. Sci. USA 102 6990
Bhat R. (2003) J. Biol. Chem. 278 45937
WO2013124413
 10.00 78
AS601245 (JNK Inhibitor V)   C20H16N6S 372.50 JNK Gaillard P. (2005) J. Med. Chem. 48 4596
Carboni S. (2005) J. Neurochem. 92 1054
WO2013152038
 10.00 67
AS601245 (JNK Inhibitor V)   C20H16N6S 372.50 JNK Gaillard P. (2005) J. Med. Chem. 48 4596
Carboni S. (2005) J. Neurochem. 92 1054
WO2013152038
 1.00 87
AX 20017   C13H16N2O2S 264.34 PknG Walburger A (2004) Science 304 1800-1804


10.00 107
AX 20017   C13H16N2O2S 264.34 PknG Walburger A (2004) Science 304 1800-1804


1.00 99
AZD8055   C25H31N5O4 465.50 mTOR C1, mTOR C2 Chresta C.M. (2010) Cancer Res. 70 288-298
Sini P. (2010) Autophagy 6(4)

0.10 104
AZD8055   C25H31N5O4 465.50 mTOR C1, mTOR C2 Chresta C.M. (2010) Cancer Res. 70 288-298
Sini P. (2010) Autophagy 6(4)

1.00 116