Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
AG1478 (Tyrphostin)   C16H14ClN3O2 315.75 EGFR Osherov N. (1994) A. Eur. J. Biochem. 225 1047


 1.00 93
AG490   C17H14N2O3 294.30 EGFR, JAK Jaleel M. (2004) Biochemistry 43 8247
Eriksen K.W. (2001) Leukemia 15 787
WO2004052359
 1.00 90
AG490   C17H14N2O3 294.30 EGFR, JAK Jaleel M. (2004) Biochemistry 43 8247
Eriksen K.W. (2001) Leukemia 15 787
WO2004052359
 10.00 125
Akti 1/2   C34H29N7O 551.60 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27
Barnett S.F. (2005) Biochem. J. 385 399
WO2013147649
 1.00 87
Amgen TBK 1 inhibitor (Compound II)   C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470


 1.00 74
Amgen TBK 1 inhibitor (Compound II)   C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470


 0.10 95
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244


 0.10 30
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244


 1.00 7
Amlexanox   C16H14N2O4 298.29 TBK1, IKKe

10.00 109
Amlexanox   C16H14N2O4 298.29 TBK1, IKKe

1.00 90