Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11


250.00 108
MLi-2   C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 35…

WO2014134774
1.00 109
MLi-2   C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 35…

WO2014134774
10.00 107
NIK-Novartis-T1-7   C18H14N6OS 362.41 NIK
US20120214762
0.10 116
OTSSP167 C25H28Cl2N4O2 487.42 MELK

0.10 92
OTSSP167 C25H28Cl2N4O2 487.42 MELK

1.00 89
PD 0325901   C16H14F3IN2O4 482.19 MEK1 Bain J. (2007) Biochem J. 408 297–315.
Barrett SD. (2008) Bioorg. Med. Chem. Lett. 18 6501-6504.
WO2002006213
1.00 106
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


1.00 111
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


10.00 96
PRT062607   C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387


0.10 85