Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26
Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37

100.00 104
EGCG (Epigallocatechin Gallate)   C22H18O11 458.40 PKC Dell'Aica I. (2004) EMBO Rep. 5 418-422
Tachibana H. (2004) Nat. Struct. Mol. Biol. 11 380
WO2001051048
10.00 66
ER-27319   C20H22N2O5 370.40 SYK Moriya K. (1997) Proc. Natl. Acad. Sci. USA 94 12539-12544


1.00 113
ER-27319   C20H22N2O5 370.40 SYK Moriya K. (1997) Proc. Natl. Acad. Sci. USA 94 12539-12544


10.00 96
ETP 46464   C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727


10.00 89
ETP 46464   C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727


1.00 91
Febuxostat (TMX-67, Adenuric, Uloric)   C16H16N2O3S 316.37 Xanthine oxidase (XO) Gaffo AL. (2010 ) Core Evid. 4 25-36
Grabowski B (2010) Br J Clin Pharmacol. 70 57-64

1.00 92
Febuxostat (TMX-67, Adenuric, Uloric)   C16H16N2O3S 316.37 Xanthine oxidase (XO) Gaffo AL. (2010 ) Core Evid. 4 25-36
Grabowski B (2010) Br J Clin Pharmacol. 70 57-64

10.00 83
FMK (Caspase Inhibitor I)   C22H30FN3O7 467.50 Caspase Martin U. (2007) Apoptosis 12 525
Misaghi S. (2004) Chem. Biol. 11 1677
WO2001058526
3.00 79
GDC-0941   C23H29N7O3S2Cl2 586.57 PI3K Folkes AJ. (2008) J Med Chem. 5522-32

WO2007129161
0.10 90