Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Zearalenone   C18H22O5 318.40 Estrogen receptor (ER) Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42


10.00 85
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


1.00 28
ZM 336372   C23H23N3O3 389.40 c-Raf Hall-Jackson C.A. (1999) Chem. Biol. 6 559


10.00 7
Celastrol   C29H38O4 450.60 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13

WO2007117466
5.00 105
Curcumin   C21H20O6 368.40 Inhibits EGF receptor Cui L. (2007) Antimicrob. Agents Chemother. 51 488
Salvioli S. (2007) eCAM 4 181
WO2000070949
10.00 102
Curcumin   C21H20O6 368.40 Inhibits EGF receptor Cui L. (2007) Antimicrob. Agents Chemother. 51 488
Salvioli S. (2007) eCAM 4 181
WO2000070949
1.00 108
HA-1077, Dihydrochloride (Fasudil)   C14H17N3O2S • 2HCl 364.30 PKA Watanabe K. (2007) Nature Biotechnology 25 681
Swärd K. (2000) J. Physiol. 522 33
WO1999041984
10.00 84
NVP-BEZ 235   C30H25Cl2N5O 542.46 PI3K, Akt, mTOR Maira S. Stauffer F. (2008) Mol. Cancer. Ther. 7 1851-1863.

WO2008064093
0.10 83
NVP-BEZ 235   C30H25Cl2N5O 542.46 PI3K, Akt, mTOR Maira S. Stauffer F. (2008) Mol. Cancer. Ther. 7 1851-1863.

WO2008064093
1.00 85
SB-747651A C16H22N8O 342.40 Naqvi (2012) Biochem. J. 441 (347–357)


0.10 101