Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Roscovitine   C19H26N6O 354.50 CDK De Azevedo W.F. (1997) Eur. J. Biochem. 243 518
Meijer L. (1997) Eur. J. Biochem. 243 527

1.00 97
Rottlerin   C30H28O8 516.50 PKC Villalba M. (1999) J. Immunol. 163 5813
Gschwendt M. (1994) Biochem. Biophys. Res. Commun. 199 93

10.00 84
Rottlerin   C30H28O8 516.50 PKC Villalba M. (1999) J. Immunol. 163 5813
Gschwendt M. (1994) Biochem. Biophys. Res. Commun. 199 93

20.00 100
Ruxolitinib   C17H18N6 306.37 JAKs Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-6…

WO2008157208
0.10 88
Ruxolitinib   C17H18N6 306.37 JAKs Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-6…

WO2008157208
1.00 39
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488


0.10 109
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488


1.00 104
SB-203580   C21H16N3OSF 377.40 p38 MAPK Powell D.J. (2003) Mol. Cell Biol. 23 7794
Davies S.P. (2000) Biochem. J. 351 95

10.00 92
SB-203580   C21H16N3OSF 377.40 p38 MAPK Powell D.J. (2003) Mol. Cell Biol. 23 7794
Davies S.P. (2000) Biochem. J. 351 95

1.00 106
SB-216763   C19H12Cl2N2O2 371.22 GSK3 Coghlan (2000) Chem.Biol. 7 793
Liang (2006) J.Biol.Chem. 282 3904

10.00 81