Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
HA-1077, Dihydrochloride (Fasudil)   C14H17N3O2S • 2HCl 364.30 PKA Watanabe K. (2007) Nature Biotechnology 25 681
Swärd K. (2000) J. Physiol. 522 33
WO1999041984
1.00 104
HA-1100 (Hydroxyfasudil)   C14H17N3O3S.HCl 343.83 ROCK S. Wolfrum (2004) Arterioscler. Thromb. Vasc. Biol. 24 1842


10.00 92
HA-1100 (Hydroxyfasudil)   C14H17N3O3S.HCl 343.83 ROCK S. Wolfrum (2004) Arterioscler. Thromb. Vasc. Biol. 24 1842


1.00 103
Harmaline   C13H14N2O 214.26 serotonin, monoamine oxidase Herraiz T. (2013) Drug Test. 1002/dta.1530.

WO1999041984
1.00 80
Harmalol   C12H12N2O • HCl • 2H2O 272.73 serotonin, monoamine oxidase Riba J. (2012) Drug Test. 610-6.

US5256533
1.00 97
Harmane   C12H10N2 182.22 serotonin, monoamine oxidase Smith KL. (2013) J Psychopharmacol. 162-70

US5256533
1.00 82
Harmine   C13H12N2O 212.25 serotonin, monoamine oxidase Song Y. (2004) Biochem. Biophys. Res. Commun. 317 128–132

US5256533
1.00 81
Harmine   C13H12N2O 212.25 serotonin, monoamine oxidase Song Y. (2004) Biochem. Biophys. Res. Commun. 317 128–132

US5256533
10.00 82
HG-10-102-01 LRRK2 Choi H.G. (2012) ACS Med. Chem. Lett.


10.00 44
HG-10-102-01 LRRK2 Choi H.G. (2012) ACS Med. Chem. Lett.


1.00 71