Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
GSK429286   C21H16F4N4O2 432.37 ROCK Goodman K. (2007) J. Med. Chem. 50 (1), 6-9
Nichols (2009) Biochem.J. 424 47

1.00 90
GSK461364   C27H28F3N5O2S 543.60 PLK1 T. R. Rheault (2010) Bioorg. Med. Chem. Lett. 20(15) 4587-92
K. A. Emmitte (2009) Bioorg. Med. Chem. Lett. 19(6) 1694-7

1.00 101
GSK461364   C27H28F3N5O2S 543.60 PLK1 T. R. Rheault (2010) Bioorg. Med. Chem. Lett. 20(15) 4587-92
K. A. Emmitte (2009) Bioorg. Med. Chem. Lett. 19(6) 1694-7

0.10 100
GSK650394A   C25H22N2O2 382.45 SGK Sherk A. B. (2008) Cancer Res 68 7475–7483


 1.00 3
GSK650394A   C25H22N2O2 382.45 SGK Sherk A. B. (2008) Cancer Res 68 7475–7483


 10.00 3
GSK650394A   C25H22N2O2 382.45 SGK Sherk A. B. (2008) Cancer Res 68 7475–7483


 0.10 28
GW441756 hydrochloride   C17H13N3O • HCl 311.77 Trk A Wood E.R. (2004) Bioorg. Med. Chem. Lett. 14 953-957


 1.00 88
GW501516   C21H18F3NO3S2 453.50 PPARd Sznaidman M.L. (2003) Bioorg Med Chem Lett 13(9) 1517-21


 1.00 89
GW501516   C21H18F3NO3S2 453.50 PPARd Sznaidman M.L. (2003) Bioorg Med Chem Lett 13(9) 1517-21


 10.00 79
GW5074 (Raf1 Kinase Inhibitor I)   C15H8Br2INO2 520.90 cRAF1 Lackey K. (2000) Bioorg. Med. Chem. Lett. 10 223

WO2010036813
 1.00 90