Inhibitor | GSK650394A  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
GSK650394A   C25H22N2O2 382.45 890842-28-1 25022668 SGK Sherk A. B. (2008) Cancer Res 68 7475–7483

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 49 6
ASK1 100 4
Aurora A 78 4
Aurora B 85 9
BRSK1 84 6
BRSK2 86 0
BTK 89 3
CAMK1 104 4
CAMKK beta 11 1
CDK2-Cyclin A 106 11
CHK1 112 2
CHK2 83 0
CK1 delta 70 4
CK2 96 1
CLK2 65 1
CSK 99 9
DAPK1 87 3
DYRK1A 79 7
DYRK2 101 4
DYRK3 79 8
EF2K 120 7
EPH-A2 92 6
EPH-A4 103 7
EPH-B1 94 2
EPH-B2 86 10
EPH-B3 108 5
EPH-B4 122 7
ERK1 105 4
ERK2 100 6
ERK8 23 0
FGF-R1 99 8
GCK
8
 0
GSK3 beta 94 1
HER4 105 1
HIPK1 99 1
HIPK2 70 4
HIPK3 100 0
IGF-1R 100 12
IKK beta 94 8
IKK epsilon 91 7
IR 111 0
IRAK4 20 2
IRR 98 2
JAK2 24 3
JNK1 81 1
JNK2 80 4
JNK3 73 0
Lck 109 3
LKB1 86 2
MAPKAP-K2 107 5
MAPKAP-K3 101 1
MARK1 97 4
MARK2 88 6
MARK3 89 6
MARK4 110 8
MEKK1 92 1
MELK 100 3
MINK1 68 0
MKK1 105 8
MKK2 93 4
MKK6 97 4
MLK1 87 7
MLK3 75 2
MNK1 28 2
MNK2 68 5
MSK1 94 2
MST2 68 6
MST4 81 1
NEK2a 114 3
NEK6 104 2
NUAK1 45 3
p38 alpha MAPK 94 4
p38 beta MAPK 109 5
p38 delta MAPK 118 7
p38 gamma MAPK 106 7
PAK2 99 11
PAK4 96 1
PAK5 110 3
PAK6 102 5
PDK1 94 5
PHK 34 0
PIM1 91 5
PIM2 104 0
PIM3 90 1
PKA 91 0
PKB alpha 104 0
PKB beta 86 9
PKC alpha 100 4
PKC zeta 96 4
PKD1 103 2
PLK1 93 1
PRAK 107 6
PRK2 76 10
RIPK2 55 0
ROCK 2 84 5
RSK1 102 2
RSK2 96 7
S6K1 100 4
SGK1 56 3
SmMLCK 87 0
Src 93 6
SRPK1 82 2
SYK 99 0
TAK1 115 10
TAO1 98 7
TBK1 86 2
TrkA 29 2
TTK 89 2
VEGFR1 98 8
YES1 105 7
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK
2
 0
Aurora B 32 0
BRSK2 61 6
BTK 96 5
CAMK1 99 4
CAMKK beta
2
 0
CDK2-Cyclin A
1
 0
CHK1 108 10
CHK2 40 4
CK1 delta 12 0
CK2 82 25
CSK 96 9
DYRK1A 47 1
DYRK2 20 0
DYRK3 57 4
EF2K 110 9
EPH-A2 97 0
EPH-B3 107 33
ERK1 75 7
ERK2 103 1
ERK8 32 0
FGF-R1 77 0
GCK
3
 0
GSK3 beta 78 3
HER4 86 0
HIPK2 58 3
IGF-1R 103 6
IKK beta 97 12
IKK epsilon 44 2
IR 100 5
IRAK4 12 3
IRR 58 9
JNK1 74 7
JNK2 46 10
Lck 79 1
LKB1 89 9
MAPKAP-K2 103 5
MARK3 60 0
MELK 27 1
MINK1 19 2
MKK1 34 2
MLK1 38 6
MLK3 33 4
MNK1
3
 0
MNK2 14 2
MSK1 103 0
MST2 22 0
MST4 68 8
NEK2a 60 9
NEK6 107 23
NUAK1 15 4
p38 alpha MAPK 119 14
p38 beta MAPK 112 8
p38 delta MAPK 87 2
p38 gamma MAPK 104 14
PAK4 85 13
PAK5 88 0
PAK6 103 1
PDK1 85 0
PHK
3
 0
PIM1 62 8
PIM2 92 11
PIM3 86 1
PKA 104 12
PKB alpha 72 4
PKB beta 98 4
PKC alpha 61 11
PKC zeta 105 4
PKD1 55 1
PLK1 31 7
PRAK 77 12
PRK2 31 1
ROCK 2 59 3
RSK1 93 5
RSK2 97 1
S6K1 74 9
SGK1
9
 1
SmMLCK 102 2
Src 102 8
SRPK1 104 4
SYK 66 11
TBK1 70 10
TTK 79 3
VEGFR1 63 6
YES1 93 1
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK
1
 0
Aurora B
6
 0
BRSK2 20 3
BTK 70 33
CAMK1 80 12
CAMKK beta
2
 0
CDK2-Cyclin A
0
 0
CHK1 79 3
CHK2 28 3
CK1 delta
3
 0
CK2 46 11
CSK 98 2
DYRK1A
8
 0
DYRK2
2
 0
DYRK3 17 4
EF2K 108 21
EPH-A2 85 3
EPH-B3 101 13
ERK1 39 2
ERK2 61 0
ERK8 23 10
FGF-R1 27 4
GCK
1
 0
GSK3 beta 23 10
HER4 71 9
HIPK2 15 3
IGF-1R 18 0
IKK beta 64 7
IKK epsilon 14 3
IR 68 16
IRAK4 12 1
IRR 26 2
JNK1 39 7
JNK2
9
 1
Lck 45 22
LKB1 61 21
MAPKAP-K2 96 7
MARK3 29 15
MELK
8
 0
MINK1
2
 0
MKK1 12 2
MLK1
7
 2
MLK3
5
 0
MNK1
3
 1
MNK2
4
 1
MSK1 62 3
MST2
4
 0
MST4 13 0
NEK2a 27 5
NEK6 107 14
NUAK1
10
 5
p38 alpha MAPK 106 3
p38 beta MAPK 71 1
p38 delta MAPK 62 1
p38 gamma MAPK 35 8
PAK4 39 2
PAK5 38 10
PAK6 61 6
PDK1 31 5
PHK
0
 0
PIM1 26 1
PIM2 75 2
PIM3 45 3
PKA 97 5
PKB alpha 57 11
PKB beta 74 8
PKC alpha 33 6
PKC zeta 87 0
PKD1 16 0
PLK1
5
 0
PRAK 73 5
PRK2
5
 1
ROCK 2 33 16
RSK1 38 4
RSK2 57 21
S6K1 24 1
SGK1
1
 0
SmMLCK 87 0
Src 44 0
SRPK1 50 0
SYK 12 1
TBK1 27 3
TTK 46 3
VEGFR1 15 0
YES1 42 2