Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
LY364947   C17H12N4 272.31 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953
Li (2006) J.Med.Chem. 49 2138

1.00 86
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


1.00 129
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


0.10 120
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


10.00 119
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11


100.00 81
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11


250.00 90
MLi-2   C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 35…

WO2014134774
1.00 125
MLi-2   C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 35…

WO2014134774
10.00 114
MLN9708   C20H23BCl2N2O9 517.12 Proteasome Kupperman. E. (2010) Cancer Research 70 1970-1980


10.00 96
MRT199665   C28H31N5O2.ClH 506.04 MARK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91

WO2009152027
1.00 84