Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Ubiquitin E1 Inhibitor (PYR-41)   C17H13N3O7 • 3H2O 425.40 Ubiquitin-E1 Yang Y (2007) Cancer Res. 67 9472


10.00 102
Uo126   C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623
Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839

10.00 86
UCN-01   C28H26N4O4 482.50 PKC Reinhardt H.C. (2007) Cancer Cell 11 175
Jiang X. (2004) Mol. Cancer Ther. 3 1221

0.01 58
Uo126   C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623
Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839

5.00 71
Volasertib   C34H50N8O3 618.81 PLK1 Rudolph D (2009) Clin Cancer Res 15(9) 3094-3102
Grinshtein N (2011) Cancer Res 71(4) 1385-1395

1.00 85
Volasertib   C34H50N8O3 618.81 PLK1 Rudolph D (2009) Clin Cancer Res 15(9) 3094-3102
Grinshtein N (2011) Cancer Res 71(4) 1385-1395

0.10 89
VPS34-IN1   C21H24ClN7O 425.91 Vps34 Bago R (2014) Biochem J.

WO2012085815
1.00 83
VPS34-IN2 (PIK-III)   C17H17N7 319.36 PI3K, VPS34 William E. Dowdle (2014) Nature Cell Biology

WO2012085815
1.00 39
VPS34-IN2 (PIK-III)   C17H17N7 319.36 PI3K, VPS34 William E. Dowdle (2014) Nature Cell Biology

WO2012085815
0.10 65
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262


1.00 7