Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
KU55933   C21H17NO3S2 395.49 ATM Li Y. (2010) Mol. Cancer Ther. 2010 Jan. 9(1) 113-25


1.00 99
KU55933   C21H17NO3S2 395.49 ATM Li Y. (2010) Mol. Cancer Ther. 2010 Jan. 9(1) 113-25


0.10 84
Leflunomide   C12H9F3N2O2 270.21

1.00 102
Leflunomide   C12H9F3N2O2 270.21

10.00 105
Lenalidomide (Revlimid) C13H13N3O3 259.26 TNF-α Rushworth S.A. (2013) Cellular Signalling 25 1 106-112


1.00 106
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11


100.00 106
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11


250.00 110
MLi-2   C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 35…

WO2014134774
1.00 105
MLi-2   C21H25N5O2 LRRK2 Matthew J. Fell (2015) Journal of Pharmacology and Experimental Therapeutics 35…

WO2014134774
10.00 89
MRT199665   C28H31N5O2.ClH 506.04 MARK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91

WO2009152027
1.00 5