Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SU-5416 (VEGFR2 Kinase Inhibitor III)   C15H14N2O 238.30 VEGF-R Tille J.C. (2003) Exp. Cell Res. 285 286
Itokawa T. (2002) Mol. Cancer Ther. 1 295

0.10 100
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319
Blake R.A. (2000) Mol. Cell. Biol. 20 9018

1.00 58
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319
Blake R.A. (2000) Mol. Cell. Biol. 20 9018

10.00 44
Sulfasalazine   C18H14N4O5S 398.39 glutathione-S-transferase Liptay S. (1999) Br. J. Pharmacol. 128 1361
Volin M.V. (1999) Arthritis Rheum. 42 1927

1.00 98
Sulfasalazine   C18H14N4O5S 398.39 glutathione-S-transferase Liptay S. (1999) Br. J. Pharmacol. 128 1361
Volin M.V. (1999) Arthritis Rheum. 42 1927

10.00 88
Sunitinib   C22H27FN4O2 398.47 RTK, Multiple Tyrosine Kinases Targeted Sakamoto K. M. (2004) Curr Opin Investig Drugs 5(12) 1329-39


 0.10 92
Sunitinib   C22H27FN4O2 398.47 RTK, Multiple Tyrosine Kinases Targeted Sakamoto K. M. (2004) Curr Opin Investig Drugs 5(12) 1329-39


 1.00 65
SYK Inhibitor I   C18H15N3O3S 353.40 SYK Lai J.Y. (2003) Bioorg. Med. Chem. Lett. 13 3111


 1.00 41
SYK Inhibitor I   C18H15N3O3S 353.40 SYK Lai J.Y. (2003) Bioorg. Med. Chem. Lett. 13 3111


 0.10 77
SYK Inhibitor II   C14H15F3N6O • 2HCl•2H2O 449.30 SYK Hisamichi H. (2005) Bioorg. Med. Chem. 13 4936


 1.00 79