Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
R-406   C23H24FN5O5 469.46 SYK Braselmann S. (2006) J Pharmacol Exp Ther. 319(3) 998-1008


 1.00 54
R-406   C23H24FN5O5 469.46 SYK Braselmann S. (2006) J Pharmacol Exp Ther. 319(3) 998-1008


 0.10 90
R-406   C23H24FN5O5 469.46 SYK Braselmann S. (2006) J Pharmacol Exp Ther. 319(3) 998-1008


 10.00 70
RO-3306   C₁₈H₁₃N₃OS₂ 351.50 Cdk1 Vassilev, L.T. (2006) Proc. Natl. Acad. Sci. USA 103 10660


 10.00 120
RO-3306   C₁₈H₁₃N₃OS₂ 351.50 Cdk1 Vassilev, L.T. (2006) Proc. Natl. Acad. Sci. USA 103 10660


 1.00 113
Ruxolitinib   C17H18N6 306.37 JAKs Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-6…

WO2008157208
 0.10 82
Ruxolitinib   C17H18N6 306.37 JAKs Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-6…

WO2008157208
 1.00 80
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488


 1.00 101
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488


 0.10 109
SB-505124   C20H21N3O2 · xHCl · yH2O 335.40 ALK Byfield (2004) Mol.Pharmacol. 65 744


 0.10 95