Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Withaferin A C28H38O6 470.60 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253


10.00 66
Withaferin A C28H38O6 470.60 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253


0.10 82
Withaferin A C28H38O6 470.60 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253


1.00 78
WNK-463   C21H24F3N7O2 463.46 WNK Yamada K (2016) Nat Chem Biol. 12(11) 896-898


1.00 102
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

5.00 99
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

1.00 98
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

1.00 98
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

5.00 99
BX-912   C20H23BrN8O 471.35 PDK Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74


0.10 9
QNZ   C22H20N4O 356.40 NF-κB

10.00 76