Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Chelerythrine Chloride   C21H18NO4Cl 383.80 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209
Jarvis W.D. (1994) Cancer Res. 54 1707
WO2003077917
0.10 105
CHIR 99021 (CT 99021)   C22H18Cl2N8 465.34 GSK3 Ring D.B. (2003) Diabetes 52 588

WO1999065897
10.00 74
CHIR 99021 (CT 99021)   C22H18Cl2N8 465.34 GSK3 Ring D.B. (2003) Diabetes 52 588

WO1999065897
1.00 81
Chloroquine   C18H26ClN3 319.87 Anti Malarial

1.00 95
Chloroquine   C18H26ClN3 319.87 Anti Malarial

10.00 115
CKI-7   C11H12ClN3O2S • 2HCl 358.67 CK1 Rena G. (2004) EMBO Rep. 5 60-65

WO2002102768
2.50 76
CKI-7   C11H12ClN3O2S • 2HCl 358.67 CK1 Rena G. (2004) EMBO Rep. 5 60-65

WO2002102768
25.00 26
Compound C (Dorsomorphin)   C24H25N5O 399.50 AMPK Yu P.B. (2008) Nat. Chem. Biol. 4 33
Kim E.K. (2004) J. Biol. Chem. 279 19970
WO2008033408A2
1.00 56
Compound C (Dorsomorphin)   C24H25N5O 399.50 AMPK Yu P.B. (2008) Nat. Chem. Biol. 4 33
Kim E.K. (2004) J. Biol. Chem. 279 19970
WO2008033408A2
0.10 99
Compound C (Dorsomorphin)   C24H25N5O 399.50 AMPK Yu P.B. (2008) Nat. Chem. Biol. 4 33
Kim E.K. (2004) J. Biol. Chem. 279 19970
WO2008033408A2
10.00 19