Inhibitor | Compound C (Dorsomorphin)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Compound C (Dorsomorphin)   C24H25N5O 399.50 1219168-18-9 11524144 AMPK Yu P.B. (2008) Nat. Chem. Biol. 4 33 Kim E.K. (2004) J. Biol. Chem. 279 19970

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 64 7
ASK1 87 0
Aurora A 117 3
Aurora B 96 10
BRSK1 91 1
BRSK2 96 4
BTK 89 3
CAMK1 117 7
CAMKK beta 56 0
CDK2-Cyclin A 71 4
CHK1 101 1
CHK2 89 4
CK1 delta 47 1
CK2 85 6
CLK2 38 0
CSK 83 6
DAPK1 103 1
DYRK1A 44 0
DYRK2 88 0
DYRK3 74 0
EF2K 81 1
EPH-A2 91 8
EPH-A4 108 13
EPH-B1 70 5
EPH-B2 80 2
EPH-B3 78 9
EPH-B4 81 3
ERK1 117 11
ERK2 84 10
ERK8 49 1
FGF-R1 90 5
GCK 29 4
GSK3 beta 70 3
HER4 104 9
HIPK1 101 0
HIPK2 93 8
HIPK3 96 2
IGF-1R 98 6
IKK beta 79 1
IKK epsilon 88 5
IR 46 12
IRAK4 103 13
IRR 69 3
JAK2 100 3
JNK1 95 1
JNK2 99 12
JNK3 89 12
Lck 73 5
LKB1 76 13
MAPKAP-K2 99 6
MAPKAP-K3 90 4
MARK1 94 6
MARK2 81 1
MARK3 99 3
MARK4 80 3
MEKK1 101 6
MELK 43 0
MINK1 62 7
MKK1 88 6
MKK2 106 1
MKK6 97 10
MLK1 70 11
MLK3 90 0
MNK1 99 4
MNK2 112 3
MSK1 91 9
MST2 92 7
MST4 99 6
NEK2a 100 8
NEK6 90 6
NUAK1 45 4
p38 alpha MAPK 103 5
p38 beta MAPK 95 9
p38 delta MAPK 104 8
p38 gamma MAPK 96 5
PAK2 111 12
PAK4 87 8
PAK5 108 4
PAK6 95 0
PDK1 102 3
PHK 43 3
PIM1 100 7
PIM2 105 4
PIM3 95 13
PKA 87 0
PKB alpha 96 2
PKB beta 90 6
PKC alpha 105 12
PKC zeta 91 13
PKD1 101 3
PLK1 105 11
PRAK 102 3
PRK2 85 12
RIPK2 23 2
ROCK 2 88 1
RSK1 91 2
RSK2 108 6
S6K1 80 0
SGK1 100 2
SmMLCK 106 9
Src 76 5
SRPK1 102 5
SYK 92 6
TAK1 71 3
TAO1 103 11
TBK1 100 12
TrkA 51 2
TTK 86 6
VEGFR1 18 0
YES1 50 3
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 27 1
ASK1 96 7
Aurora A 87 6
Aurora B 51 8
BRSK1 83 4
BRSK2 94 7
BTK 61 12
CAMK1 94 13
CAMKK beta 25 2
CDK2-Cyclin A 40 4
CHK1 107 6
CHK2 75 7
CK1 delta 14 0
CK2 45 0
CLK2
9
 1
CSK 68 5
DAPK1 88 5
DYRK1A
8
 0
DYRK2 47 0
DYRK3 27 0
EF2K 77 3
EPH-A2 66 1
EPH-A4 52 2
EPH-B1 25 1
EPH-B2 21 3
EPH-B3 32 3
EPH-B4 26 2
ERK1 107 8
ERK2 76 2
ERK8
8
 1
FGF-R1 36 2
GCK
9
 2
GSK3 beta 65 8
HER4 94 4
HIPK1 64 3
HIPK2 32 3
HIPK3 99 3
IGF-1R 103 14
IKK beta 69 9
IKK epsilon 67 5
IR 40 12
IRAK4 44 2
IRR 47 5
JAK2 107 12
JNK1 95 3
JNK2 120 9
JNK3 94 2
Lck 24 1
LKB1 83 4
MAPKAP-K2 115 8
MAPKAP-K3 94 3
MARK1 71 7
MARK2 73 9
MARK3 72 0
MARK4 74 2
MEKK1 99 11
MELK 27 2
MINK1 20 0
MKK1 101 1
MKK2 92 11
MKK6 103 2
MLK1 53 2
MLK3 42 4
MNK1 56 4
MNK2 56 1
MSK1 68 5
MST2 85 4
MST4 115 3
NEK2a 97 1
NEK6 101 9
NUAK1 34 13
p38 alpha MAPK 98 7
p38 beta MAPK 78 3
p38 delta MAPK 99 13
p38 gamma MAPK 102 0
PAK2 118 13
PAK4 75 4
PAK5 96 11
PAK6 110 14
PDK1 122 6
PHK 15 10
PIM1 84 2
PIM2 108 4
PIM3 105 11
PKA 87 2
PKB alpha 94 1
PKB beta 81 11
PKC alpha 96 9
PKC zeta 87 3
PKD1 97 15
PLK1 89 6
PRAK 117 3
PRK2 40 5
RIPK2
9
 1
ROCK 2 80 1
RSK1 75 6
RSK2 104 7
S6K1 70 3
SGK1 84 0
SmMLCK 120 4
Src 37 1
SRPK1 108 3
SYK 83 1
TAK1 21 0
TAO1 85 3
TBK1 61 7
TrkA 24 4
TTK 83 6
VEGFR1 18 3
YES1 18 0
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 16 1
ASK1 89 2
Aurora A 23 4
Aurora B 17 0
BRSK1 36 4
BRSK2 27 0
BTK 30 8
CAMK1 53 0
CAMKK beta 21 2
CDK2-Cyclin A
8
 1
CHK1 47 1
CHK2 36 6
CK1 delta
2
 0
CK2
8
 1
CLK2
1
 0
CSK 17 1
DAPK1 33 1
DYRK1A
2
 0
DYRK2
9
 0
DYRK3
5
 0
EF2K 72 9
EPH-A2 40 1
EPH-A4
10
 2
EPH-B1
6
 1
EPH-B2
10
 2
EPH-B3
10
 0
EPH-B4
5
 0
ERK1 117 13
ERK2 71 2
ERK8
2
 1
FGF-R1 11 2
GCK
5
 2
GSK3 beta 21 1
HER4 61 13
HIPK1 18 2
HIPK2
6
 1
HIPK3 29 2
IGF-1R 77 11
IKK beta 54 3
IKK epsilon 22 0
IR 22 3
IRAK4 11 1
IRR 21 1
JAK2 57 0
JNK1 101 1
JNK2 87 7
JNK3 56 1
Lck
5
 0
LKB1 85 1
MAPKAP-K2 90 3
MAPKAP-K3 86 15
MARK1 45 1
MARK2 62 4
MARK3 19 0
MARK4 63 7
MEKK1 67 9
MELK 16 0
MINK1
4
 2
MKK1 57 2
MKK2 71 12
MKK6 96 1
MLK1 25 6
MLK3
7
 0
MNK1 19 4
MNK2 25 5
MSK1 15 1
MST2 83 6
MST4 67 10
NEK2a 60 6
NEK6 82 3
NUAK1 17 3
p38 alpha MAPK 107 12
p38 beta MAPK 50 7
p38 delta MAPK 85 11
p38 gamma MAPK 67 12
PAK2 86 3
PAK4 44 1
PAK5 57 2
PAK6 63 1
PDK1 88 7
PHK
2
 0
PIM1 48 5
PIM2 96 1
PIM3 52 4
PKA 44 2
PKB alpha 35 2
PKB beta 40 2
PKC alpha 75 4
PKC zeta 53 4
PKD1 56 12
PLK1 78 1
PRAK 78 10
PRK2 14 4
RIPK2
7
 2
ROCK 2 18 4
RSK1 22 2
RSK2 50 4
S6K1 29 1
SGK1 23 3
SmMLCK 56 6
Src 14 1
SRPK1 98 3
SYK 39 6
TAK1
5
 2
TAO1 62 8
TBK1 19 1
TrkA 11 5
TTK 32 3
VEGFR1 15 0
YES1
8
 3