Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
PD 0325901-Cl (CI-1055-S)   C16H14O4N2F2ClI 498.65 MEK1
WO2002006213
10.00 61
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


1.00 98
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


0.10 95
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


10.00 91
Piceatannol   C14H12O4 244.20 PKA, SYK Wang B.H. (1998) Planta Med. 64 195
Keely P.J. and Parise L.V. (1996) J. Biol. Chem. 271 26668
WO2012021964
10.00 101
Piceatannol   C14H12O4 244.20 PKA, SYK Wang B.H. (1998) Planta Med. 64 195
Keely P.J. and Parise L.V. (1996) J. Biol. Chem. 271 26668
WO2012021964
1.00 99
Pirfenidone   C12H11NO 185.23 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125
Iyer (1999) J.Pharmacol.Exp.Ther. 289 211
WO2005040758
1.00 106
Pirfenidone   C12H11NO 185.23 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125
Iyer (1999) J.Pharmacol.Exp.Ther. 289 211
WO2005040758
10.00 88
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


10.00 12
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8


1.00 20