Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
LY364947   C17H12N4 272.31 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953
Li (2006) J.Med.Chem. 49 2138

1.00 119
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


1.00 110
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


0.10 97
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448


10.00 99
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11


100.00 100
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11


250.00 95
MK-2206   C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43


10.00 80
MK-2206   C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43


0.10 80
MK-2206   C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43


1.00 75
ML-7, Hydrochloride   C15H17IN2O2S • HCl 452.70 MLCK Krarup T. (1998) Am. J. Physiol. 275 C239
Saitoh M. (1987) J. Biol. Chem. 262 7796
WO1999041984
20.00 70