Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

5.00 95
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

1.00 103
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

1.00 103
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

5.00 95
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


0.10 51
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549


1.00 40
Chelerythrine Chloride   C21H18NO4Cl 383.80 PKC Kandasamy R.A. (1995) J. Biol. Chem. 270 29209
Jarvis W.D. (1994) Cancer Res. 54 1707
WO2003077917
10.00 70
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.


1.00 23
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 94
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 95