Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
PD 0325901-Cl (CI-1055-R)   C16H14O4N2F2ClI 498.65 MEK1
WO2002006213
10.00 98
PD 0325901-Cl (CI-1055-Racemic mix of isomers)   C16H14O4N2F2ClI 498.65 MEK1
WO2002006213
1.00 101
PD 0325901-Cl (CI-1055-Racemic mix of isomers)   C16H14O4N2F2ClI 498.65 MEK1
WO2002006213
10.00 107
PD 0325901-Cl (CI-1055-S)   C16H14O4N2F2ClI 498.65 MEK1
WO2002006213
1.00 89
PD 0325901-Cl (CI-1055-S)   C16H14O4N2F2ClI 498.65 MEK1
WO2002006213
10.00 108
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


10.00 76
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


1.00 113
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797


0.10 120
Pirfenidone   C12H11NO 185.23 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125
Iyer (1999) J.Pharmacol.Exp.Ther. 289 211
WO2005040758
10.00 112
Pirfenidone   C12H11NO 185.23 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125
Iyer (1999) J.Pharmacol.Exp.Ther. 289 211
WO2005040758
1.00 106