Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
HG-9-91-01   C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91


 0.10 119
HG-9-91-01   C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91


 1.00 128
HG-9-91-01   C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91


 0.01 110
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381
A. Zhao (1999) J. Antibiot. 52 1086

0.10 103
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381
A. Zhao (1999) J. Antibiot. 52 1086

1.00 109
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381
A. Zhao (1999) J. Antibiot. 52 1086

0.01 105
IKK Inhibitor VII   C28H29N5OS 483.60 IKK Waelchli R. (2006) Bioorg. Med. Chem. Lett. 16 108


 1.00 80
IKK Inhibitor VII   C28H29N5OS 483.60 IKK Waelchli R. (2006) Bioorg. Med. Chem. Lett. 16 108


 10.00 32
IKK-2 Inhibitor IV (TPCA-1)   C12H10FN3O2S 279.30 IKK2 Podolin P.L. (2005) J. Pharmacol. Exp. Ther. 312 373
Karin M. (2004) Nat. Rev. Drug Discov. 3 17
WO2008144011
 10.00 14
IKK-2 Inhibitor IV (TPCA-1)   C12H10FN3O2S 279.30 IKK2 Podolin P.L. (2005) J. Pharmacol. Exp. Ther. 312 373
Karin M. (2004) Nat. Rev. Drug Discov. 3 17
WO2008144011
 1.00 62